· COMPREHENSIVE

Distribution & Cold Chain (GDP)

Protecting product quality after release — through storage, transport, and the supply network.

QMM · Business ContinuityGDPGood Distribution Practice
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WHY IT MATTERS

Product quality can be lost after it leaves the manufacturing site. Temperature excursions in transport and trading with unqualified supply partners are frequent Good Distribution Practice findings — and a cold-chain failure can quietly compromise a product that passed every release test.

WHAT GOOD LOOKS LIKE

The observable evidence a practitioner — or an inspector — would expect at each maturity level. Drawn from the assessment questions themselves.

How is temperature control maintained across storage and transport?

1Foundational

Storage monitored; transport largely unmonitored

2Defined

Temperature mapping done once; transport spot-checked

3Managed

Qualified storage plus monitored transport with MKT-based excursion evaluation per EU GDP

4Quantified

End-to-end continuous monitoring with automated excursion alerts and trending

5Optimized

End-to-end predictive cold chain: continuous monitoring, automated MKT excursion modelling, and ongoing route / lane optimisation

How are distribution suppliers and customers qualified?

1Foundational

Minimal checks before trading

2Defined

Initial bona-fide checks that are not routinely refreshed

3Managed

Documented qualification with periodic re-checks per GDP

4Quantified

Risk-scored supply-chain qualification integrated with falsified-medicine controls

5Optimized

Continuously risk-scored supply network with automated bona-fide verification and integrated anti-falsification controls

COMMON INSPECTION FINDINGS
  • Transport not temperature-monitored or qualified; no MKT-based excursion evaluation.
  • Storage areas not temperature-mapped, or monitoring with coverage gaps.
  • Suppliers and customers not qualified (bona-fide checks), or not periodically re-verified.
  • Weak controls against falsified medicines and inadequate handling of returns.
RECOMMENDED SPEQ RESOURCES
STANDARDEU GDP Guidelines (2013/C 343/01)STANDARDWHO GDP (TRS 957, Annex 5)
ALL DOMAINS
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FDA QMM
How this rolls up to Business Continuity →
THE FRAMEWORK
Where this domain sits in the operating model →