RECORDREFERENCE OUTLINE

Quality & Regulatory Due-Diligence Checklist

A structured checklist for the quality and regulatory diligence stream in a transaction: regulatory standing and inspection history, quality-system health, data integrity, validation and facilities, supply chain and recalls, a findings/remediation summary, and post-close integration readiness. The quality practitioner’s contribution to a deal — not legal, financial, or transaction advice. Structured on ICH Q10, ICH Q9(R1), 21 CFR 211, and EU GMP Chapter 1.

What a template is not

A template is a document baseline to adapt inside your own quality system. SPEQ does not approve, validate, or take responsibility for what you issue from it, and using one is not evidence of compliance.

CHECKING ACCESS

Checking your Professional access…

REGULATIONS MAPPED
ICH Q10ICH Q9(R1)21 CFR 211EU GMP Chapter 1
DOCUMENT TYPE
Record
LAST UPDATED
August 2026
PURPOSE

A structured checklist for the quality and regulatory diligence stream in a transaction — the quality practitioner’s contribution to a deal team’s work. It enumerates the evidence to request, the regulatory standing to verify, and the findings to cost, so nothing load-bearing is missed. It explains how quality connects to a transaction; it is not legal, financial, valuation, or transaction advice.

What's Inside

Regulatory standing & inspection history (classifications, 483s, warning letters, consent decrees, open commitments)
Quality-system health (deviation/CAPA ageing, change control, audits, PQRs, quality metrics)
Data integrity & computerised systems (governance, audit-trail review, validation state, hybrid/legacy gaps)
Validation, qualification & facilities (facility/equipment/process/cleaning validation, contamination control)
Supply chain, product quality & recalls (supplier qualification, single-source exposure, complaints, recalls, shortages)
Findings summary with severity, remediation scope, estimate, and state
Post-close integration readiness (QMS harmonisation, open-commitment carry-forward, tech-ops readiness, day-one accountability)

How to Use It

1Set the target and transaction context, then work each diligence area in turn
2Record status as Y (satisfactory), N (missing/unsatisfactory), or N/A with a reason
3For every N, describe the finding and its risk and carry it to the findings summary
4Judge the state of each finding — open vs. closed and verified — not just its existence
5Scope each material finding into remediation cost so the deal team can reserve or allocate it
6Confirm the acquirer can own every open regulatory obligation on day one
DOCUMENT CONTENTS

The full section structure of this template — every section and sub-section, so you can use it as a baseline for your own site document.

Document Control
Document InformationApproval SignaturesRevision HistoryDistribution List
1Purpose, Scope, and How to Use
How to use
2Regulatory Standing & Inspection History
3Quality System Health
4Data Integrity & Computerised Systems
5Validation, Qualification & Facilities
6Supply Chain, Product Quality & Recalls
7Findings Summary, Remediation & Reserves
8Post-Close Integration Readiness
REGULATORY CONTEXT

Structured on ICH Q10 (the pharmaceutical quality system), ICH Q9(R1) (quality risk management), 21 CFR 211, and EU GMP Chapter 1. Accountability for product quality stays with the authorisation holder and transfers with the asset, which is why the checklist scopes open commitments and post-close integration deliberately. The checklist structure is SPEQ synthesis; the regulatory concepts it organises are established.

MAPPED STANDARDS
ICH Q10ICH Q9(R1)21 CFR 211EU GMP Chapter 1
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