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FEDERAL REGISTER · NOTICENovember 26, 2025NOTICE — NO LEGAL EFFECT

Cross-Center Master Files: Where To Submit; Draft Guidance for Industry; Availability

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Document details are published in the U.S. Federal Register; SPEQ surfaces them for reference and is not affiliated with or endorsed by the FDA or the Office of the Federal Register. The authoritative text is on federalregister.gov.

Document type
Notice
Agency
Health and Human Services Department
Published
November 26, 2025
Comments close
February 24, 2026
Document number
2025-21224
ABSTRACT

The Food and Drug Administration (FDA, Agency, or we) is announcing the availability of a draft guidance for industry entitled "Cross-Center Master Files: Where to Submit." The draft guidance provides recommendations to industry, specifically master file holders, regarding where (i.e., to which FDA center) to submit a master file that is referenced in and intended to support more than one regulatory submission for which the lead center for those submissions may vary or where the information in the master file may need to be accessed and reviewed by more than one center to support review of the referencing submission(s). The recommendations apply to master files submitted to the Center for Biologics Evaluation and Research (CBER), the Center for Drug Evaluation and Research (CDER), the Center for Devices and Radiological Health (CDRH), and certain types of master files submitted to the Center for Veterinary Medicine (CVM).

Abstract as published in the Federal Register.

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