[ ADVERSE-EVENT SAFETY SIGNALS ]

What the post-market record is reporting.

Aggregate adverse-event volumes and the most-reported terms across FDA’s post-market systems — drug (FAERS), device (MAUDE), food (CAERS), and veterinary — the pharmacovigilance signal that shows where harm is being reported across every regulated industry.

861,573
FAERS · drug
3,051,041
MAUDE · device
4,241
CAERS · food
47,578
VET · veterinary
3,964,433 events reported across all sources (rolling 12 months) · source: openFDA event APIs
READING THESE AS A QUALITY SIGNAL — A SPEQ INTERPRETATION

Adverse-event reporting is the post-market half of the quality system. SPEQ reads these signals through two maturity lenses: Pharmacovigilance (GVP)— the maturity of a firm’s signal detection and reporting — and Data Integrity, because a report is only as trustworthy as the record behind it. High volumes are a function of both real events and reporting completeness, so counts compare reporting activity, not risk.

Pharmacovigilance (GVP) →Data Integrity (GDocP) →
FAERS
FAERS — drug adverse events · top reported terms
off label use52,144
drug ineffective46,917
death32,979
product dose omission issue32,144
nausea28,682
fatigue27,918
diarrhoea26,704
pruritus21,410
headache21,007
dyspnoea19,725
rash19,164
vomiting18,534
MAUDE
MAUDE — device adverse events · top reported terms
endosseous dental implant598,025
continuous glucose monitor336,346
alternate controller enabled insulin infusion pump304,292
automated insulin dosing device system, single hormonal control136,639
continuous glucose monitoring system122,283
implant, endosseous, root-form69,427
set, administration, intravascular60,721
automated dispensing cabinet59,004
pump, infusion46,034
pacemaker/icd/crt non-implanted components45,952
ventilator, non-continuous (respirator)43,762
dental implant40,827
CAERS
CAERS — food, supplement & cosmetic events · top reported terms
nausea1,224
diarrhoea1,143
vomiting1,026
fatigue713
hypersensitivity623
pain594
headache576
hospitalisation410
malaise329
pyrexia322
abdominal pain upper270
abdominal pain248
VET
Animal & Veterinary adverse events · top reported terms
vomiting4,906
lack of efficacy (ectoparasite) - flea4,077
lack of efficacy (endoparasite) - heartworm3,726
lethargy (see also central nervous system depression in neurological)3,587
diarrhoea2,902
lack of efficacy - nos2,689
lack of efficacy (endoparasite) - hookworm2,670
medication error nos2,092
seizure nos1,746
intentional misuse1,654
lack of efficacy (bacteria) - borrelia1,643
not eating1,572

Data: U.S. FDA openFDA event APIs (FAERS, MAUDE, CAERS, animal & veterinary), aggregate counts only over the rolling 12 months — no individual case records are stored or shown. Reported terms and volumes reflect reporting activity and completeness, not confirmed causation or comparative risk. The GVP / Data-Integrity framing is a SPEQ interpretation.